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RESEARCH ACTIVITIES and PROJECTS |
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BIOMATERIALS PHARMACEUTICALS BIOPOLYMERS INDUSTRIAL ENZYMES
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qScreening, isolation and
identification of extremophiles (Halophiles and
alkaliphiles) and yeast as a potential
sources of biopolymers (poly-3-hydroxybutyrate and bacterial
cellulose), compatible solids (proline, ectoine, hydroxyectoine) and
industrial enzymes (penicillin G acylase, amylase, lipase, protease,
phythase, cellulase, laccase etc.) qOptimization of culture and/or
fermentation conditions to increase productivity of biopolymers, industrial
enzymes and other bioactive compounds
qRecover bioactive
compounds with selective downstream processing techniques qFormulation of bioactive
compounds for industrial use qCharacterization, stabilization
and immobilization of industrially important enzymes q Development
of Bioprocess Strategies for Bio-similar Pharmaceutical |
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BIOFUELS |
q Second
and Third Generation of Biofuel Production |
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q Assessment
of the Potential Use of Agricultural Wastes for Biofuel Production |
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q Determination
of lipid profiles of microalgae in order to determine biofuel productivity |
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OMIC’S APPROACHES |
q Determination
of anti-viral, anti-microbial and anti-oxidant activity of proteins and hydrolysates and determination of structural properties |
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q Understanding of microbial responses
under extrem conditions using
proteomic tools. |
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q Using mathematical tools to relate
proteomic findings to flux distributions to elucidate new communication
networks. |
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q Metabolic
Biomarkers: A Pathway Enrichment Analysis of Alzheimer's Disease, Parkinson's
Disease, and Amyotrophic Lateral Sclerosis |
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q Proteomic Analysis of Kidney
Transplantation |
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LIST OF SELECTED PROJECTS
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Production of Bio-similar Pharmaceuticals
“TUBITAK-KAMAG-1007 Project” (Project Manager; In collaboration with Prof Dr Eda
Tahir Turanlı and Assoc. Prof.
Dr. Gizem Dinler Doğanay/ İstanbul
Technical University & with Zeynep Atabat/Atabay Pharmaceutical
Company)
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Production of
Poly(3-hydroxybutyrate) from Novel Bacillus
marmarensis GMBE 72T isolated
from mushroom compost: FEN-C-YLP-080715-0341(Project Manager)
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Production of
fermentable sugars by hydrolyses of haselnut husk, TUBITAK:
113M053 (Project Manager)
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Determination of lipid profiles of microalgae in order
to determine biofuel productivity, -FEN-A-090512-0162. (Project Manager)
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Formulation of
alkaline protease for liquid detergent, KOSGEB.
(Consultant)
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Using recycled protein waste for Oncorhynchus mykiss feed as an alternative protein source, TUBITAK-TEYDEB.
(Consultant)
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Production of industrial enzymes intended for feed
industry. TUBITAK: KAMAG-107G246.(Researcher) (In collaboration with Prof Dr Burhan
Arına, Prof Dr Sadık Dinçer and Prof Dr Hatice Korkmaz
Güvenmez/ Çukurova
University; Prof Dr Gaye Öngen/Ege University; Assoc Prof Dr Sevnur Mandacı/
TUBITAK-MAM-GMBE)
Ø Investigation of the kinetic parameters
of Bacillus subtilis SDP1 amylase
immobilized on magnetic alginate gels-FEN-D-280214-0047 (Project Manager)
Ø Immobilization of lipase on magnetic-nano particles- FEN-C-YLP-060510-0142-(Project Manager)
Ø Proteomic Investigation of the
adaptation of Halomonas halophila
DSMZ4770 at high salt concentration and low temperatures - FEN-D-040609-0179
Ø Proteomic analysis of the metabolic
pathways of halophilic microorganisms and flux analysis -
FEN-C-DRP-181208-0286.
Ø Production of amylase enzyme from
agricultural waste using Halomonas
sp. isolated from Çamaltı Saltern
Area FEN-YLS-290506-0115
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Extremophiles
as source of natural products useful for biotechnological applications: Studies
of osmoregulation strategies by engineering tools. TUBITAK:
TBAG-110T174.(Project Manager) (In collaboration with Assoc Prof Annarita Poli and Prof Barbara
Nicolaus/ CNR-ITALY)
Ø Proteomic
Analyses of Kidney Transplantation Solutions .
TUBITAK: SBAG-110S103.
(Project Manager at Marmara University) (In collaboration with Prof Dr Abdurrahman Coşkun/ Acıbadem University)
Ø Establishment
of Bioremediation Laboratory in the Bioengineering Department. Marmara
University Research Fund Project, FEN-E.-. (Project
Manager)
Ø Production and
characterization of phytase enzyme for animal feed.
Marmara University Scientific Research Project: FEN-C-DRP-171108-0267. (Project Manager)
Ø Establisment of Microbial resource Center Infrastructure for Enzyme Industry in Turkey. T.R.
Prime Ministry State Planning Organisation (DPT), conducted at TUBTAK MRC,
GEBI. (Project Manager)
Ø Investigation
of the effect of environmental conditions on newly isolated halophilic
microorganisms by proteomics. TUBITAK: MAG 104M236. (Project Manager)
Ø Production of
alpha-amylase from Halomonas sp. isolated from
Çamaltı Saltern Area by
agricultural waste. Marmara University Scientific Research Project:
FEN-YLS-290506-0115.
(Project Manager)
Ø Identification
of archaea isolated from extreme environments in Turkey and extremozymes
of these microorganisms. TUBITAK: TBAG 103T069.
(Project Manager) (In collaboration with Dr Aziz Akın Denizci/TUBITAK-MRC-GEBI)
Ø Stability,
conformational characterization and biocatalytic
applications of native and modified alkaline proteases purified from alkaliphilic Bacillus
strains. conducted at TUBTAK-MRC, GEBI. TUBITAK: TBAG-U/123 (104T262).(Researcher)
(in collaboration with Prof
Francesco Secundo/CNR-Italy)
Ø BIOCHIPBOARD
(Fungal enzymes on the production of whitelined chipboard:
technological and economic implications. conducted at TUBTAK-MRC, GEBI (In
collaboration with Prof
Candan Tamerler/ITÜ; Prof Tajelli Keshewards/University of
Westminster, KARTONSAN). EUREKA: E2184.
(Coordinator)
Ø Isolation and
identification of industrially important protein producing bacteria from local
ecosystems. TUBITAK: GMBAE F990201. (Project
Manager) conducted at TUBTAK-MRC, GEBI.
Ø Identification
of alkaline protease producing microorganisms from local ecosystems and
production and purification of alkaline protease enzyme. Marmara University
Scientific Research Project: BSE 073/131102.
(Project Manager)
Ø Traditional and
modern solutions for lactose defficiency in Turkey:
Production and development of lactase enzyme used in milk industry, YUUP-DPT
(T.R. Prime Ministry State Planning Organisation BAP-08-11-DPT 2005K120570. (Project Manager at Marmara University
Site) (In collaboration with Prof Şebnem Harsa/ İzmir Institute of
Technology)
Ø Determination
of anti-viral, anti-microbial and anti-oxidant activity of whey proteins and
hydrolysates and determination of structural properties. TUBITAK: SBAG. (Manager at Marmara University Site)(
In collaboration with Prof Süha Yalçın/Marmara University
and Prof Nazlı Arda/İstanbul
University)
Ø Sub-Project 2.2 Penicillin Acylase Production
in “Biotechnology-Establishment and Promotion of New Biotechnological
Techniques in Turkey (NATO-TU BIOTECHNOLOGY)” NATO-SFS (TUBİTAK-MAM-GMBAE)
(Researcher) conducted at TUBTAK-MRC, GEBI.
BSc Projects
(TUBITAK-2209)
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Investigation of the
inactivation kinetics of Bacillus
licheniformis BA17 alkalen protease at different pH values (MURAT ÖZKAN,
Chemical Engineering Department)
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Optimization of Phenol Removal
using Halomonas sp. AAD12 (Fatma Ece Altınışık,
Bioengineering Department)