Ahmet ARMAN

 

 

Education and Degrees:

 

Postdoct: Harvard Medical School, Harvard University, 2001

PhD: Molecular and Cellular Biology, Ohio University, 1999

MSc: Molecular Genetics, Ohio State University, 1992

BSc: Department of Biology, Uludag University, 1987

 

Area and Interests:

Molecular Mechanism of Growth and Inflammation related diseases

 

Current Position:

Associate Professor

 

ADDRESS:

Marmara University

College of Engineering (CE), CE Building D
Molecular Genetics and Cell Culture Lab, #:405

Goztepe Campus, 34722 Istanbul, Turkey

 

Tel:  (0216) 348-0292/608 (Office), 727 (lab)

Fax: (0216) 345-0126

Email:ahmetarman@marmara.edu.tr

 

teachıng courses

Molecular Genetics, Molecular Biology, Signal Transduction, Molecular Biology Lab., Medical Genetics, Human Molecular Genetics, Prokaryotic and Eukaryotic Gene Expresssion, Cell Culture Techniques, Genetic Engineering, Recombinant DNA Technology, Cell Biology, Yeast Genetics, Drosophila Genetics, Biotechnology, Microbiology,

 

Employment

Associate Prof. Department of Engineering, Marmara University, 2009-

Assistant Prof. Department of Engineering, Marmara University, 2002-2008

Postdoct, Harvard Medical School, Harvard University, 1999-2001.

Teaching Assistant, Department of Biological Sciences, Ohio University, 1996-1999.

Lab Technician, In the laboratory of Dr. John Kopchick, Edison Biotechnology Institute, Ohio University, 1995-1996.

Biology Teacher, Adana Erkek High School

 

MSc Students and THEIR Thesis:

 

Coker, A. “Determination of the relationship between Coronary Artery Disease and IL-1 RN  gene polymorphism at molecular level”, Marmara University, 2005.

 

Becit, K., “Determination of the relationship between IL-1 family gene polymorphisms and Parkinson disease” Marmara University, 2008. 

 

Sarioz O., “Determination of the relationship between IL-6 polymorphisms and rheumatoid arthritis disease at molecular level” Marmara University, 2009.

 

PhD student and Thesıs:

Coker, A.,” Cloning of human growth hormone gene, expression in both mammalian and bacteria and characterization of growth hormone deficiency disease in Turkish children”, Marmara University, 2009.

 

GRANTS:

·        Determination of Cathepsin k mutations in Pycnodysostosis patients and the relationship between phenotype and genotypes, MU Scientific Research Fund, Health, Researcher and Project designer,  2009, 40 000 TL.

 

·        Genetic characterization of children with isolated growth hormone deficiency, Tubitak Fast Fund program,  SBAG-HD-282 (107S442), Principle investigator, 2008, 20 000 TL.

 

·        The relationship between IL-6 promoter polymorphisms and Rheumatoid Arthritis at molecular level, MU Scientific Research Fund, HEALTH-067/060904, Principle investigator, 2006, 7.500 YTL.

 

·        The relationship between Interleukin 1 Family polymorphisms and Rheumatoid Arthritis, MU Scientific Research Fund, HEALTH -067/060904, Principle investigator, 2006, 18.955 YTL.

 

·        Determination of the relationship between Coronary Artery Disease and IL-1 RN  gene polymorphism at molecular level, MU Scientific Research Fund, HEALTH- 067/060904, Principle investigator, 2006, 4.378 YTL.

 

·        Determination of children with laron syndrome in Turkey, Goverment Planning Inst., K120810, Principle investigator, 2005, 250.000 YTL .

 

 

·        The relationship between Interleukin 1 Family polymorphisms and Parkinson Disease, MU Scientific Research Fund, Principle investigator, 2007, 4.750 YTL.

 

·        Characterization of molecules involved in IL-1 and IL-18 signaling in Behcet’s diseas, MU Scientific Research Fund,  Principle  investigator, 2007, 40.000 YTL

 

·        Determination of the relationship between IL-1 gene family polymorphisms and MS diseases at Molecular level, Göztepe Government Hospital, Principle investigator, 2007, 4000 YTL.

 

·        Cloning of human growth hormone gene, expression in both mammalian and bacteria and characterization of growth hormone deficiency disease in Turkish children, MU Scientific Research Fund,  Principle investigator, 2007, 22. 500 YTL

 

·        Genetic Characterization of Pycnodysostosis patients MU Medical School Foundation. Researcher, 2007, 4.500 YTL.

 

 

MOLECULAR GENETICS AND CELL CULTURE LABORATORY

Molecular Genetics and Cell Culture Lab was set up by Government Planning Inst. and Marmara University Research Funds.

 

Honors and Awards

1-2 years fellowship from Harvard Medical School

2-2.5 years stipend from Molecular and Cellular Biology program in Department

of Biological Sciences, Ohio University.

3- 6 years scholarship from Ministry of Education of Turkey for M.S. and Ph.D. in USA.

4- 3 years scholarship from Uludag University for Bachelor degree.

 

 

Current Research interests

A) Genomics and Diseases (Regarding to Inflammation, Dr. Siyami Hersek Hospital, Marmara Medical School, Goztepe Government Hospital)

 

  • The relationship between Interleukin 1 Family polymorphisms and Rheumatoid Arthritis
  • The relationship between IL-6 promoter  polymorphisms and Rheumatoid Arthritis
  • The relationship between Interlekin 1 Family polymorphisms and Coronary Artery Disease
  • The relationship between Interlekin 1 Family polymorphisms and Parkinson  Disease
  • The relationship between Interleukin 1 Family polymorphisms and Myocardial Infarction
  • The relationship between Interleukin 1 Family polymorphisms and MS disease
  • The relationship between Interleukin 1 Family polymorphisms and Atrial Vibration

 

 

 

B) Human Growth Hormone Receptor Studies (Hacettepe Medical School, Goztepe Government Hospital and Cukurova Medical School)

 

 

  • Genetics Characterization of Children with Laron in Turkey
  • Site-direct mutagenesis of mutations found in children with Laron on GHR cDNA and express and show the function of mutation in the cell culture system.

 

C) Human Growth Hormone Studies

  • Cloning of both hGH genomic and  hGH cDNA genes from human
  • Expression of hGH genomic and cDNA genes in the CHO cells and show the functions
  • Expression  of hGH cDNA gene cloned into pGEX vector in the BL21 E. coli, purified and show the function of GH-fusion protein

 

D) Characterization of isolated GHD children in Turkey (Istanbul Acibadem Hospital,  Suleyman Demirel Medical School, Anakara Diskapi Children Hospital, Ankara Medical School)

  • Characterization of  children with GHD syndrome by PCR and sequencing
  • Site directed mutagenesis of hGH gene with PCR technique
  • Express GH analogues in the CHO cells
  • Show the function of GH mutation with luciferase assay

 

E) Pycnodysostosis studies (Marmara Medical School and other hospitals)

 

  • Characterization of  pycnodysostosis patients in Turkey by PCR and sequencing
  • In vitro mutagenesis of cathepsin K gene based on natural mutations
  • Express cathepsin K analoques in mammalian  cells
  • Show function of natural mutations in the cells expressing these cathepsin k mutations

 

 

F) Characterization of molecules involved in IL-1 and IL-18 signaling in neutrophils of  behcet’s patients

  • Neutrophil isolation from behçet patient and controls
  • IL-1 and IL-18 treatment on neutrophils
  • Looking for signaling molecules

 

 

Past research interests

 

Postdoct

 

a) Characterization of molecules involved in Interleukin 1 signaling (IL-1) using Hep3B cell lines

 

b) Elucidation of domains in intracellular domain of Interleukin 1 Receptor involved in

     IL-1R signaling.

 

c) Characterization of Stat3 molecules induced by IL-1 and the interaction of Stat3 with NF-kb

 

 

Ph.D.

 

a) In vitro isolation and characterization of single stranded derived aptamers specific for the   extracellular domain of Growth Hormone Receptor (GHR). Also, long term objective, use these aptamers as therapeutic agents to treat people suffering from advense effects of excessive Growth hormone (GH), for example in acromegaly, gigantism and diabetes.

 

b) In vitro  mutagenesis studies on the extracellular and intracellular region of Growth    

      Hormone Receptor (GHR) for aptamer targeting.

 

c) Characterization of mutated and deleted motifs of the intracellular and the

      extracellular domain of GHR in cell culture systems.

 

 

Research skills

 

Transformation, miniprep and large scale plasmid isolation, expression of prokaryotic genes in E. coli, GST-pull down assay, in vitro translation, cloning of cDNA and genomic genes, polymerase chain reaction (PCR), DNA sequencing, southern, northern, western, slot blotting, receptor binding, restriction digestion, restriction mapping, ligation and in vitro mutagenesis, internalization, selection of ssDNAs for target protein (in vitro selection or SELEX), screening library, cell culture, transfection, isolation of stable clones, EMSA, expression of mammalian genes in the mammalian cells, luciferase reporter assay.

 

 

CONFERECES/SEMINARS ATTENDED

1-     DNA Technology Meeting, Columbus OH/USA,1992

2-     Endocrine Society Meeting, Washington DC/USA, 1995

3-     Istanbul Oncology Symposium, Istanbul/Turkey, 2002.

4-     Biyomut 2002

5-     The 2002 Oncology Meeting in Istanbul, TURKEY

6-     Biyomut 2004

7-     To day and Tomorrow for Arteriosclerosis Symposium, Istanbul/TURKEY, 2005

8-     Genetics Diagnostics, American Hospital, 2005

9-     DNA Computing , Turing Days’2005

10- Pharmogenetics studies in Medical applications for individual medicine Symposium, Istanbul, 2006 TURKEY.

11- Biyomut 2006

12- International Gene Therapy Symposium, Istanbul, 2007.

13- Antioxidative Stress and Antioxidants: Life it is not so simple, Molecular Medicine, 2007.

 

 

REVIEWER

International Cytokine, European Cytokine Network, Clinical and Experimental Immunology, Human Immunology

 

ADMINISTRATIVE JOBS:

Member of Research Center for Natural and Water Plants in Marmara University, 2006-

MEMBERSHIPS:

 The Endocrine Society Membership, International, Cytokine Society Membership, Medical Biology and Genetics Membership

TALKS:

 

1.      The Functional domains of GHR are involved in GH-signaling (1999) Pulmonary Biology Division, University of Cincinnati, USA.

2.      Characterization of intracellular regions of the GHR involved in GH-signaling (2000) Harvard Medical School, Boston, MA, and USA.

3.      Growth Hormone Signaling Pathway (2000) Molecular Biology and Genetics Department, Bogazici University, Istanbul/Turkey.

4.      Characterization of molecules involved in IL-1 signaling (2001) Harvard Medical School, Boston, MA, USA.

5.      Primer Design and Comparison of DNA (2002) Institute of Pure and Applied Sciences, Marmara University

6.      MSc and PhD Education in USA (2002)

7.      Stat3 is activated by Interleukin 1(IL-1) and interacts with NF-kB in The IXth International Symposium on Biomedical Sciences & Technology, 2002, Antalya, TURKEY.

8.      Growth Hormone Signaling, Functional Studies on Growth Hormone Receptor for GH-JAK-STAT Signaling, Biomed2004, Ankara.

9.      Arman A, Yılmaz B, Coker A, Inanc N, Direskeneli H, Determination of the relationship between IL-1RN and IL-1 B Gene  Polymorphisms and Rheumatoid Arthritis, Rheumatology, 2005, Konya, Turkey.

10.   Growth Hormone Signaling (2004) Istanbul Technical University.

11.  Ahmet Arman, Alev Ozon, Pınar S. Isguven, Nursen Yordam, Ajda Coker, Ismail Peker. Mutations of the Growth Hormone Receptor Gene in Turkish patients with Laron-type dwarfism, FEBS 2006.

12.  Ajda Coker, Ahmet Arman, Ozer Soylu, Aydın Yıldırım, Nesrin Ercelen, Hakkı Aydogan, Tuna Tezel: “Interleukin-1 Receptor Antagonist 2/2 Genotype is associated with Single Vessel Coronary Artery Disease in Turkish Population, FEBS 2006. This study was granted by FEBS with Young Scientist Grant.

13.  Ahmet Arman1,  Ajda Coker2,  Ergun Çetinkaya3, Bumin Dündar4, Zeynep Sıklar5, Atilla Büyükgebiz6 “Characterization of function of mutations found in GH gene of  IGHD in mammalian Cell Culture, XIII Pediatric Endocrinology and Diabetes Congress. November 17-21, 2009, Antalya. 

14.  Ajda Coker1, Ahmet Arman2, Bilgin Yüksel3,  Fatih Temiz3, Ali Kemal Topaloglu3 Screening of mutations in GHR gene of patients with Laron syndrome and Determination of biological acivity of a novel W104R mutation in Cell Culture System,  XIII Pediatric Endocrinology and Diabetes Congress. November 17-21, 2009, Antalya.  This research was rewarded by mansion grant

15.  Ahmet Arman, Cloning, Expression of hGH gene and Genetic characterization of children with IGHD, 1th Biotechnology Congress, 2010, Yeditepe University, Istanbul

 

 

PUBLICATIONS:

Science-index

A1. A. Arman2, A. Coker3, O. Sarioz1, N.  Inanc4, H. Direskeneli4, Lack of association between IL-6 gene polymorphisms and Rheumatoid Arthritis (Revision)

A2. Ahmet Arman1, Bilgin Yüksel2, Ajda Coker3, Ozlem Sarioz4, Fatih Temiz2, Ali Kemal Topaloglu2 ,  Novel Growth Hormone Receptor gene mutation in a patient with Laron Syndrome  Journal of Pediatric Endocrinology & Metabolism, Volume 23; 407-414,  2010.

A3. Ahmet Arman, Nihal Isik, Ajda Coker,  Fatma Candan,  Kezban Serap Becit, and  Edward O. List, The association between Sporadic Parkinson Disease and Interleukin-1B -511 gene polymorphism in Turkish population,  European Cytokine Network,  Jun 1;21(2):116-121. 2010.

A4. Ajda Coker, Ergun Cetinkaya, Bumin Dundar, Zeynep Siklar, Atilla Buyukgebiz, Ahmet Arman,  Characterization of GH-N mutations in children with isolated Growth Hormone Deficiency in Turkish Population, Journal of Pediatric Endocrinology & Metabolism, November 22; 1937-946, 2009.

A5. Ahmet Arman, Ergun Cetinkaya, Bumin Dundar, Zeynep Siklar, Ajda Coker, Atilla Buyukgebiz Characterization of GH-N mutations in children with isolated Growth Hormone Deficiency in Turkish Population, Hormone Resarch (Abstract, 2009).

A6. Arman A, Ozon A, Isguven PI, Coker A, Peker I, Yordam N. “Novel Splice Site Mutation in the Growth Hormone Receptor Gene in Turkish patients with Laron-type dwarfism”, (Journal of Pediatric Endocrinology & Metabolism, Jan 21;47-58 2008.

A7. Arman A, Yılmaz B, Coker A, Inanc N, Direskeneli, H. “Interleukin-1 Receptor Antagonist (IL-1RN) and Interleukin-1B  gene Polymorphisms in Turkish patients with Rheumatoid Arthritis”, Clin Exp Rheumatol., Nov-Dec;24(6):643-8, 2006.

A8. Yoshida Y, Kumar A, Koyama Y, Peng H, Arman A, Boch JA, Auron PE. “Interleukin 1 activates STAT3/nuclear factor-kappaB cross-talk via a unique TRAF6- and p65-dependent mechanism“. J Biol Chem. 2004 Jan 16;279(3):1768-76.

A9. Geckil H, Arman A, Gencer S, Ates B, Yilmaz HR. “Vitreoscilla hemoglobin renders Enterobacter aerogenes highly susceptible to heavy metals”
Biometals. 2004 Dec;17(6):715-23.

A10. Arman A, Auron PE. “Interleukin 1 (IL-1) induces the activation of Stat3”.
Adv Exp Med Biol. 2003;534:297-307.

A11. Soylu O, Yıldırım A, Coker A, Tezel T, Arman A. “Interleukin-1 B (-511) gene polymorphism is associated with acute coronary syndrome in turkish population” Eur Cytokine Netw. 2008 Mar;19(1):42-8.

A12. Arman A, Soylu O, Yıldırım A, Ercelen N, Aydogan H, Coker A, Tezel T. “Interleukin-1 receptor antagonist gene vntr polymorphism is associated with coronary artery disease Arq Bras Cardiol 2008, 91 (5):268:273.

A13. Arman A, Ozon A, Isguven PS, Yordam N, Coker A, Peker I. “Mutations of the Growth Hormone Receptor Gene in Turkish patients with Laron-type dwarfism”, FEBS JOURNAL 273: 45-45 Suppl. 1 JUN 2006 (Abstract).

A14. Coker A, Arman A, Soylu O, Yıldırım A, Ercelen N, Aydogan H, Tezel T. “Interleukin-1 Receptor Antagonist 2/2 Genotype is associated with Single Vessel Coronary Artery Disease in Turkish Population”, FEBS JOURNAL 273: 211-211 Suppl. 1 JUN 2006 (Abstract).

A15. Yoshida Y, Arman A, Bach J, et al. Cross-talk between Stat3 and NF kappa B (p65) results in inhibition of APRE-like GAS sites and cooperativity on unique composite GAS/kappa B site, FASEB J 16 (4): A172-A173 Part 1 MAR 20 2002 (Abstract).

A16. Yoshida A, Boch J, Koyama Y, et al. Interleukin 1 activates Stat3 via the TRAF domain of TRAF6, FASEB J 15 (5): A905-A905 Part 2 MAR 8 2001 (Abstract).

 

POSTER PRESENTATION (INTERNATIONAL)  

 

B1. Arman A, Kelder B Xu B, Wang X, and Kopchick JJ, “Repositioning of a growth hormone receptor intracellular domain which is required for STAT5 activation”. The Endocrine Society Program and Abstracts P2-353, 1996.

B2. Arman A, Kelder B, Okada S and Kopchcik JJ. “The effect of deletion and repositioning of intracellular regions of the GHR on GH mediated signal transduction”. The Endocrine Society Program and Abstracts P2-228, 1997.

B3. Arman A, and Kopchcik JJ. “The porcine growth hormone receptor Box 1 alterations affect STAT5 activation”. The Endocrine Society Program and Abstracts P2-242, 1998.

B4. Arman A, Billestrup N, Kelder B, Bellush LL and Kopchick JJ. “Positive and negative regulatory elements may be involved in regulation of GH signaling”. The Endocrine Society Program and Abstracts P2-242, 1999.

B5. Arman A, and Auron P E. “IL-1 induces tyrosine and serine phosphorylation of Stat3”. FASEB meeting and Abstracts LB157, 2000.

B6. Arman A, Ergene A and Kopchick JJ.  “Amino acid residues in the extracellular domain of GHR affect on GHR signaling”. FASEB Meeting and Abstracts LB158, 2000.

B7. Arman A, and KopchickJJ. “STAT5 phosphorylation depends on JAK2 activation” FASEB meeting and Abstracts LB159, 2000.

B8. Yoshida Y, Jason, Boch, AJ, Koyama Y and Arman A. “TRAF domain of TRAF6 activates Stat3”. Harvard Medical School, HIM Retreat, 2001.

B9. Arman A. “GTP-binding domain exchange between Elongation factor Tu (EF-Tu) and EF-G”. Ohio University, Molecular and Cellular Biology Meeting, 1999.

B10. Arman A. “Serine and Tyrosine and PI3 kinases are involved in the regulation of Interleukin –1 (IL-1) induced-Stat3 activation”. The IXth International Symposium on Biomedical Sciences & Technology,  Antalya, TURKEY, 2002.

B11. Arman A, and Kopchick JJ. “Isolation of Single-stranded aptamers for growth hormone receptor”. 1st International Meeting on Medicinal and Pharmaceutical Chemistry IMMPC-1, Ankara, TURKEY, 2002.

B12. Arman A. (2003) “The Box 3 region of Growth Hormone Receptor may act dual functions: Stat5 activation and Phosphatase binding”. 2003.

B13. Arman A, and Coker A. “Growth Hormone Antagonist, G120K treated-Cell Line Expressing W122A mutation of GHR did not reverse STAT5 phosphorylation”, Advances in Molecular Medicine Symposium, P153, 2005.

B14. Arman A. “Applications of Aptamers in Medicine”, Advances in Molecular Medicine Symposium, P155, 2005.

B15. Arman A, and Coker A. “Applications of Ribozymes in Medicine”, Advances in Molecular Medicine Symposium, P156, 2005.

B16. Arman A and Coker A. “JAK2 is not involved in the regulation the activation of Stat3-induced by IL-1”,  11 th International Biomedical Science and Technology Days, Biomed 2004, Ankara, Turkey, 2004.

B17. Arman A. “Negative-Dominant IkB Kinase inhibits NF-kB and APRE Reporter Plasmids”,  11 th International Biomedical Science and Technology Days, Biomed 2004, Ankara, Turkey, 2004.

B18. Arman A. and Coker A. “The Effect of Sodium Arsenite and 15-deoxyD12, 14-PGJ2 on IL-1 induced hSIE, StatBE, NF-kB and APRE Reporter Plasmids”, 11 th International Biomedical Science and Technology Days, Biomed 2004, Ankara, Turkey, 2004.

B19. Arman A.  “Growth Hormone Signaling, Functional Studies on Growth Hormone Receptor for GH-JAK-STAT Signaling”, 11 th International Biomedical Science and Technology Days, Biomed2004, Ankara, 2004.

B20. Arman A and  Coker A. “The prevalence of Interleukin-1 Receptor Antagonist gene (IL-1RN) VNTR polymorphism in Turkish Population”, Advances in Molecular Medicine, 2007.

B21. Coker A and Arman A.  “No association between IL-1 Alpha (A) polymorphism and Coronary Artery Disease (CAD) in Turkish Population”, Advances in Molecular Medicine, 2007.

B22. Becit S, Arman A, Coker A, Isık N, and Candan F. “The lack association between Interleukin 1 A gene and Parkinson Disease in Turkish Population”, Advances in Molecular Medicine , 2007.

B23. Arman A, and Kopchick JJ. Growth Hormone Receptor Box 1 Deletion  Inhibits JAK2/STAT5 Activation, Proceedings of International Symposium on Health Informatics and Bioinformatics, 115-120, 2005.

B24. Arman A, and Kopchick JJ. W122A mutation on Growth Hormone receptor did not reverse STAT5 phosphorylation. Proceedings of International Symposium on Health Informatics and Bioinformatics, 121-125, 2005.

B25. Arman A, Billestrup N, List E, and Kopchick JJ. Box 3 region involved in the regulation of spi gene activation. Proceedings of International Symposium on Health Informatics and Bioinformatics, 127-133, 2005.

B26. Arman A and Auron PP. “Stat3 is activated by Interleukin 1(IL-1) and interacts with NF-kB” in the IXth  International Symposium on Biomedical Sciences & Technology, 19-22 Eylül, 2002, Antalya, Türkiye.

B27. Ahmet Arman, Ajda Coker, Ozer Soylu, Aydin Yildirim, Tuna Tezel. “A genetic association between Myocardial Infarction (MI) and Interleukin-1 B (+ 3953) gene polymorphism in turkish population”15.BCLF Symposium, Antalya, 2007.

B28. Serap Turan, Ahmet Arman, Tulay Guran, Teoman Akcay, Ajda Coker, Abdullah Bereket. Novel Mutations in cathepsin K gene in Turkish patients with pycnodysostosis  Hormone Research, European Society for Paedatric Endocrinology (ESPE2007).

B29. Pinar Isguven, Ahmet Arman, Metin Yildiz, Ilknur Arslanoglu, Ajda Coker, Muferred Erguven. Novel Splice site mutation of growth hormone receptor gene in Turkish boy with Laron syndrome, European Society for Paedatric Endocrinology (ESPE2007).

B30. Ahmet Arman, Ergun Cetinkaya, Bumin Dundar, Zeynep Sıklar, Ajda Coker, Atilla Buyukgebiz Characterization of GH-N mutations in children with isolated Growth Hormone Deficiency in Turkish Population, European Society for Paedatric Endocrinology (ESPE2008).

B31. Ahmet Arman1, Ajda Coker2,  Ergun Cetinkaya3, Bumin Dundar4, Zeynep Sıklar5 Ozlem Sarıoz6, Atilla Buyukgebiz7 , Genetic characterization of children with isolated Growth Hormone Deficiency in Turkish Population, (ECE2009).

B32. Ajda Coker1,  Ahmet Arman2, Ozlem Sarıoz3, Alev Ozon4 , Splice site mutation on the growth hormone receptor (GHR) causes Laron type- Dwarfism (ECE2009).

 

D. Papers published in National journals

D1. Arman A. “Biochips: New method in DNA Technolgy”, Healthy Journal, May, No: 135, Page:18-20 (2003).

D2. Arman A. “The use of Ribozymes in Medicine”, Healthy Journal, May, No: 140, Page: 50-54 (2003).

D3. Arman A.   “DNA-Based DNA Technology”, Healthy Journa (2003).

 

POSTERS (National)

 

E1. Arman A. “The eefcet of Early Growth Response Transcription Factor-1 on  Acute Phase Response and NF-KB reporteri, VI National Prenatal Diagnıstics and Medical Genetics Symposium, 2004, Antalya, TURKEY.

E2. Arman A, Yılmaz B, Çoker A, Inanc N, Direskeneli H, Determination of the relationship between RA disease and IL-1 RN and IL-1 B polymorphisms in Turkish Population Rheumatology, 2005, Konya, TURKEY.

E3. Coker A, Arman A, Soylu O, Yildirim A, and Tezel T. “Interleukin-1 B (-511) gene polymorphism is associated with acute coronary syndrome in Turkish population” (National Medical Biology and genetics Symposium, P34, 2007, Antalya, TURKEY.

E4. Becit S, Arman A, Coker A,  Isık N, Candan F. “Interleukin-1 Receptor Antagonist (IL-1RN) and Interleukin-1B gene Polymorphisms with Parkinson Disease in Turkish population” National Medical Biology and Genetics Symposium, P36, 2007, Antalya, TURKEY.

E5. Sarioz O, Arman A, Coker A,  Becit S, Direskeneli H. Lack of association between Interleukin-1 Alpha (-889) gene polymorphisms and Rheumatoid Arthritis in Turkish population. X. National Medical Biology and Genetics Symposium, P92, 2007, Antalya, TURKEY.

 

E6. Sarıoz O, Arman A, Çoker A, Inanc N, Direskeneli H, Determination of the relationship between IL-6 promoter  polymorphisms and Rheumatoid Arthritis in Turkish Population

Rheumatology, 2008, Antalya, TURKEY