| |
Bilimsel Çalışmaları |
|
| |
|
|
| |
Bilimsel Yayınları :
1. Yüksek Lisans Tezi :
"Bazı Hipnotik-Sedatif Etkili İlaç Maddelerinin
Yüksek Basınçlı Sıvı Kromatografisi ile Miktar
Tayinleri"
(Marmara Üniversitesi Sağlık Bilimleri Enstitüsü
Farmasötik Kimya Anabilim Dalı, Nisan 1987)
2. Doktora Tezi :
"The Metabolic and Chemical Determinants of
Amide Formation from Benzylic Amines"
(University of London, Nisan 1992)
3. Uluslararası dergilerde yayınlanmış makaleler
:
1. Rollas, S., Buyuktimkin, S., Buyuktimkin, N.,
Ulgen, M., Yemni, E.
"Evaluation of some arylhydrazones of N2-arylidene
benzylic acid hydrazide
as antimicrobial agents" Pharmazie, 43 , 511
(1988).
2. Buyuktimkin, S., Rollas, S., Ulgen, M., Otuk,
G.
"Some 1,3,4-oxadiazoline derivatives prepared by
starting from benzylic acid
aryl hydrazones and their antimicrobial
evaluation" Pharmazie, 45 , 865 (1990).
3. Ulgen, M., Gorrod, J.W.
"Microsomal formation of N-benzyl-4-hydroxymethylaniline
from N-benzyl-4-methylaniline"
J. Pharm. Pharmacol, 44, 865-866 (1992).
4. Low,C. M., Ulgen, M., Gorrod, J.W.
"The recognition of a diarylimine as a
metabonate produced during incubation
of N-benzyl-4-chloroaniline with hepatic
microsomal preparations"
J.Pharm.Pharmacol., 46 , 585-590 (1994).
5. Gorrod, J.W., Ulgen, M.
"Metabolic N-oxidation of diarylimines: A new
metabolic
reaction of potential toxicological significance"
Drug.Met.Rev., 26 , 241-252 (1994).
6. Ulgen, M., Gorrod, J.W.
"Metabolic & chemical studies on N,-diarylnitrones"
Drug Metab. Drug Interact., 11 245-257 (1994).
7. Ulgen, M., Gorrod, J.W., Barlow, D.
"Structure-activity relationships in the
formation of
amides from substituted N-benzylanilines"
Xenobiotica, 24 , 735-748 (1994).
8. Ulgen, M., Kajbaf, M., Lamb, J., Jahanshahi,
M.,
Gorrod, J.W., Naylor, S.
"Characterization of N-benzylcarbazole and its
metabolites from microsomal
mixtures by tandem mass spectrometry"
Europ.J.Drug Met. Pharmacokin., 19 , 343-348
(1994).
9. Komurcu, S.G., Rollas, S., Ulgen, M., Gorrod,
J.W., Cevikbas,A.
"Evaluation of some arylhydrazones of p-aminobenzoic
acid hydrazide as
antimicrobial agents and their in vitro
microsomal metabolism"
Boll.Chim.Farm., 134 , 375-379 (1995).
10. Gulerman, N., Rollas, S., Ulgen, M., Gorrod,
J.W.
"Synthesis and evaluation of some substituted
1,3,4-thiadiazole derivatives"
Boll.Chim.Farm., 134 , 461-463 (1995).
11. Ulgen, M., Yilmaz, F., Unsalan, S., Gorrod,
J.W.
"Chemical and metabolic studies on
N-benzyl-tert-butylamine and its potential
metabolites" Drug Metab. Drug Interact., 12 ,
131-143 (1995).
12. Ulgen, M., Gorrod, J.W.
"The failure of Substrate pKa to influence the
Microsomal formation of
Amides from N-Benzylamines : The Microsomal
metabolism of
N-benzylpyrrolidine, N-benzylcarbazole and
N-acetyl-N-benzyl-4-
methylaniline
J.Pharm.Pharmacol., 48 , 1320-1326 (1996).
13. Ulgen, M., Erçak, K., Küçükgüzel, I.,
Gorrod, J.W.
"In vitro microsomal metabolic studies on
secondary aromatic amides"
Boll.Chim.Farm., 136, 239-243 (1997).
14. Ulgen, M., Durgun, B.B., Rollas, S., Gorrod,
J.W.
"The in vitro hepatic microsomal metabolism of
benzoic acid benzylidene
hydrazide"
Drug Metab. Drug Interact., 13, 285-294 (1997).
15. Ulgen, M., Ozer, U., Kucukguzel, I., Gorrod,
J. W.
"Microsomal metabolism of
N-benzyl-N-ethylaniline and N-benzyl-N-ethyl-p-
toluidine"
Drug Metab. Drug Interact., 14, 83-98 (1997).
16. Kucukguzel, I., Ulgen, M., Gorrod, J.W.
"In vitro microsomal metabolism of nuclear
chlorine substituted secondary amines
and imines" Europ.J.Drug Met. Pharmacokin., 22,
351-358 (1997).
17.Tunc, N.,Yilmaz, F., Ulgen, M., Gorrod, J.W.
"In vitro metabolic N- and C-oxidation of
Phenanthridine"
Europ.J.Drug Met. Pharmacokin., 22, 345-349
(1997).
18. Eldirdiri, N., Ulgen, M., Jacob, P., Gorrod,
J.W.
"The in vitro metabolism of norcotinine and
related biotransformation products
by microsomal preparations"
Europ.J.Drug Met. Pharmacokin., 22, 385-390
(1997).
19. Jacob, P., Ulgen, M., Gorrod, J.W.
"Metabolism of (S)-(-) Nicotine by guinea pig
and rat brain: Identification of
cotinine" Europ.J.Drug Met. Pharmacokin., 22,
391-394 (1997).
20. Gülerman, N., Rollas, S., Ulgen, M.
"Synthesis and in vitro microsomal metabolism of
4-ethyl-5-(4-fluorophenyl)-
2,4-dihydro-3H-1,2,4-triazole-3-thione and its
potential metabolites"
Boll.Chim.Farm., 137, 239-242 (1998).
21. Ulgen, M.
"Chemical Artifacts in Drug Metabolism Research"
Boll. Chim. Farm., 138, 388-396 (1998).
22. Kaymakçıoğlu, B., Oruç, E., Rollas, S.,
Ulgen, M.
"The in vitro hepatic microsomal metabolism of
3,5-dimethyl-4-phenylazo
(1H) pyrazole in rats"
Drug Metab. Drug Interact., 15, 107-114 (1999).
23. Yılmaz, F., M. Ulgen, M., Gorrod, J.W.
"The in vitro hepatic microsomal metabolism of
N-benzyladamantanamine
in rats" Drug Metab. Drug Interact., 15, 115-125
(1999).
24. Ulgen, M., Yılmaz, F., Doğruer, D.S., Şahin,
M.F.
"The in vitro hepatic microsomal metabolism of
methyl 2-(2(3H)-
benzoxazolone-3-yl)acetate in rats"
Drug Metab. Drug Interact., 15, 173-179 (1999).
25. Yılmaz, F., Ulgen, M., Doğruer, D,S., Çakır,
B., Şahin, M.F.
The in vitro hepatic metabolism of
1-phenyl-2-(2-benzothiazolinone-
3-yl)ethanone and their reduced derivatives
Experimental and Toxicological Pathology, 51,
178-181 (1999).
26. Kucukguzel, I., Ulgen, M., Gorrod, J.W.
"In vitro hepatic microsomal metabolism of
N-benzyl-N-methylaniline"
Farmaco, 54, 331-337 (1999).
27. Ülgen, M., Gorrod, J.W.
“Studies on the in vitro hepatic microsomal
formation of amides during the
metabolism of certain secondary and tertiary
benzylic amines”
Europ.J.Drug Met. Pharmacokin., 25, 145-150
(2000).
28. Küçükgüzel, G., Küçükgüzel, İ., Ülgen, M.
“Metabolic and chemical studies on
N-(4-chlorobenzyl)-N’-benzoylhydrazine”
Farmaco, 55, 624-630 (2000).
29. Şimşek,R., Şafak,C., Erol, K., Ataman, Ş.,
Ülgen, M., Linden, A.
“Synthesis, evaluation of the Calcium
Antagonistic Activity and Biotransformation of
Hexahydroquinoline and Furoquinoline
Derivatives” Arzneimittel Forschung Drug
Research , 53,
159-166 (2003).
30. Bilgiç, D., Pekin, M., Karaderi, S., Ulgen,
M.
“The determination of Stability Constants of
para Substituted N-Benzylideneaniline Metal
Complexes by a Potentiometric Method” Reviews in
Analytical Chemistry, 23 (2), 107-121 (2004).
31. Bulut, G., Oktav, M., Ulgen, M.
“The Stability Studıes and In Vıtro Hepatic
Microsomal Metabolism of Some
a-Phenyl-N-Substıtuted
Nitrones in Rats” Europ.J.Drug Met.
Pharmacokin., 29 (4), 237-248 (2004).
32. Yılmaz, F., Arıcıoğlu Kartal, F., Ulgen, M.
and Gorrod, J.W.
“In Vitro Hepatic Microsomal Metabolism of
N-Benzyl and N-Benzoylnornicotine Derivates by
Rat”
Europ.J.Drug Met. Pharmacokin., 29 (4), 249-256
(2004).
33. Bekce, B., Sener, G., Oktav, M., Ulgen, M.
And Rollas, S.
“In vitro and in vivo metabolism of ethyl
4-[(2-hydroxy-1-naphthyl)azo]benzoate”
Europ.J.Drug Met. Pharmacokin., 30 (2), 91-97
(2005).
34. Oktav, M. and Ulgen, M.
“The Evaluation of Printability and Biochemical
Stability of 4’-Chlorophenylazo-2-Naphtole for
use as a
Printing Dye”
Surface Coatings International , 88 (3), 185-188
(2005).
35. Aydın, F., Şafak, C., Şimşek, R., Erol, K.,
Ülgen, M., Linden, A.
“ Studies on condensed 1,4-dihydropyridine
derivatives and their calcium modulatory
activities”
Pharmazie, 61 (8), 655-659 (2006).
36. Oruç, E.E., Koçyiğit-Kaymakçıoğlu, B.,
Yılmaz-Demircan, F., Gürbüz, Y., Kalaça, S.,
Küçükgüzel,
Ş.G., Ülgen, M., Rollas, S.
“An high performance liquid chromatographic
method for the quantification of cotinine in the
urine of
preschool children” Pharmazie, 61 (10), 821-827
(2006).
4. Ulusal dergilerde yayınlanmış makaleler :
1. Yars, U., Ulgen, M.
"The assay of some sedative drugs by high
pressure liquid chromatography"
J.Pharm.Univ.Mar., 4, 53-61 (1988).
2. Rollas, S., Dogan, N., Ulgen, M., Ozger, Y.
"Synthesis and spectrometric analysis of some
new azopyrazole substituted
1,2,4-triazole-5-thiones"
J.Pharm.Univ.Mar., 6, 41-47 (1990).
3. Güldür, T., Ulgen, M., Ulutin, T.
"Şilomikron ve Şilomikron Artık Metabolizması"
Endokrinolojide yönelişler, 2 , 19-21 (1990)
4. Ulgen, M., Gorrod, J.W.
"Synthesis and characterization of some new
2,4,6-trisubstituted N,N-dibenzylanilines"
J.Pharm.Univ.Mar., 7, 25-32 (1991).
5. Ulgen,M., Gorrod, J.W.
"Synthesis,characterization and chromatographic
studies on some substituted
a,N-diphenylnitrones"
J.Pharm.Univ.Mar., 8, 135-143 (1992).
6. Ulgen, M.
"İn vitro Oksidatif Mikrozomal 1.faz İlaç
Metabolizması Teknikleri"
J.Pharm.Univ.Mar., 9, 165-185 (1993).
7. Ulgen, M., Gorrod, J.W.
"Synthesis, isolation and characterisation of
some substituted N-benzyl and
N-benzoylanilines".
J. Fac. Pharm. Ist., 30 , 1-9 (1994).
8. Gulerman, N., Rollas, S., Ulgen, M.
"Synthesis of some substituted 1,2,4-thiadiazole
derivatives"
J.Pharm.Univ.Mar., 10 , 17-25 (1994).
9. Kucukguzel, I., Rollas, S., Ulgen, M.
"Synthesis and characterization of some thiourea
derivatives from 1,3,4-
triazoline-3-thiones"
J.Pharm.Univ.Mar., 10 , 11-16 (1994).
10. Yılmaz, F., Ulgen, M.
"In vitro microsomal metabolism of some N-benzyl
substituted tertiary amines
in the rat"
Acta Pharm. Turcica, 4 , 171-180, (1997).
11. Unsalan, S., Ulgen, M.
"In vitro microsomal metabolism of
N,N-dibenzylmethylamine,
N,N-dibenzyl-4-nitro and
N,N-dibenzyl-2,4-dichlorobenzylamine"
Fabad J. Pharm. Sci., 22, 103-109, (1997).
12. Kucukguzel,I., Ulgen, M.
"In vitro metabolic fate of N-substituted
Dibenzylamines : Investigation of Biological
Oxidation Site
on Nitrogen Compounds with Different pKa"
J. Fac. Pharm. Ist., 32, 69-86, (1998).
13. Bulut, G., Oktav, M. ve Ülgen, M.
"Nikotin ve günümüzde sigara kullanımı" Basev
dergisi, 20, 25-30 (2000).
14. Ulgen, M.
“İlaçların eliminasyonuna yardım eden önemli bir
mekanizma : İlaç metabolizması”
Havan, 2, 12-15 (2000)
15. Ulgen, M.
“İlaçların ve diğer kimyasalların metabolizması”
Kimya Teknolojileri, 5, 58-60 (2001)
16. Oktav, M., Şekercioğlu, Y., Zelzele, Ö.,
Ülgen, M.
“Karton ambalaj sektöründe sağlığı ve
işgüvenliğini olumsuz etkileyen faktörlerin
önlenmesine
yönelik inceleme” Plastik ve Ambalaj
Teknolojisi, 67, 42-51 (2002).
17. Yılmaz, F., Ulgen, M.
“Organizmamızı tehdit eden bir bileşik :
Nikotin”
Kimya Teknolojileri,17, 40-43 (2002).
18. Ulgen,M., Yılmaz, F.
“Yüksek Basınçlı Sıvı Kromatografisinin İlaç
Endüstrisinde Kullanımı”
Kimya Teknolojileri,23, 46-51 (2002).
5. Uluslararası bildiriler :
1. M.Ulgen, J.W.Gorrod
"Microsomal metabolism of N-benzyl-4-methyl and
2,4,6-trimethylaniline
Fourth Stowe School Symposium on Drug Metabolism
April 2-5,1990, Stowe School, Buckinghamshire,
UK.
2. M.Ulgen, J.W.Gorrod
"The effect of ring substitution on the
formation of amide metabolites from N-
benzyl anilines"
UK Drug Metabolism Spring Meeting 17-18th
April,1991,
University of Nottingham, Nottingham,UK.
3. M.Ulgen, M.Kajbaf, J.W.Gorrod
"Microsomal metabolism of N-benzylcarbazole"
UK Drug Metabolsm Spring Meeting 17-18th
April,1991,
University of Nottingham, Nottingham,UK.
4. M.Ulgen, J.W.Gorrod
"Screening for microsomal formation of amides
from certain benzylic amines"
Third International ISSX Meeting, Drug
Metabolism:
Molecules,models and man. 24-28 June,1991,
Amsterdam,The Netherlands.
5. M.Ulgen, J.W.Gorrod
"Nitrones as precursors of amides in metabolic
studies"
Fourth European ISSX Meeting
Toxicological Evaluation of Chemical
Interactions:
Relevance of Social Enviromental and
Occupational
Factors", July 3-6,1992. Bologna, Italy.
6. M.Ulgen, B.B.Durgun, S.Rollas, G.Altuntas,
J.W. Gorrod
"The in vitro hepatic oxidative microsomal
metabolism of N-benzilidenebenzoic
acid hydrazide"
3rd International Symposium of Pharmaceutical
Sciences. Ankara University, Faculty of
Pharmacy,
June 15-18,1993, Ankara.
7. N.N.Gulerman, S.Rollas, M.Ulgen
"Synthetic routes to some substituted
1,3,4-thiadiazole derivatives starting from 1-
aroyl-4-substituted thiosemicarbazides"
3rd International Symposium of Pharmaceutical
Sciences.Ankara University, Faculty of Pharmacy,
June 15-18,1993, Ankara.
8. M.Ulgen, J.W.Gorrod.
"Metabolic and chemical determinants of amide
formation from benzylic amines"
3rd International Symposium of Pharmaceutical
Sciences. Ankara University, Faculty of
Pharmacy,
June 15-18,1993, Ankara,Turkey.
(Sözlü Bildiri)
9. J. W. Gorrod, M. Ulgen
"Metabolic N-oxygenation of diarylimines: A new
metabolic reaction"
Nato Advanced Study Institute, Molecular aspects
of oxidative drug
metabolising enzymes and their significance in
enviromental toxicology,
chemical carcinogenesis and health, June 20-July
2,1993,
Kuşadası, Turkey.
(Sözlü Bildiri)
10. Komurcu, S.G., Ulgen,M., Rollas,S., Sezen,S.
"The in vitro hepatic oxidative microsomal
metabolism of 4-aminobenzoic acid
p-fluorobenzalhydrazone"
World Congress of Pharmacy and Pharmaceutical
Sciences (FIP'93), September 5-10,1993,
Tokyo,Japan.
11. Kucukguzel,I., Rollas,S., Ulgen,M.
"Synthesis and anti-bacterial activity of
certain thiourea derivatives obtained
from 1,3,4-triazoline-3-thiones.
World Congress of Pharmacy and Pharmaceutical
Sciences (FIP'93), September 5-10,1993,
Tokyo,Japan.
12. M.Ulgen., J.W.Gorrod, S.Unsalan, F.Yilmaz.
"Metabolic and chemical studies on
aryl-alkylimines and their potential
metabolites"
First International Meeting on Scientific Basis
of Modern
Pharmacy, June 8-11,1994, Athens, Greece.
13. G.Aislaitner, M.Ulgen, J.W. Gorrod.
"In vitro microsomal metabolic studies on
secondary aromatic amides:
Comparative rates of hydrolysis"
First International Meeting on Scientific Basis
of Modern
Pharmacy, June 8-11,1994, Athens, Greece.
14. M.Ulgen, J.W.Gorrod.
"Chemical artifacts in drug metabolism research"
First International Meeting on Pharmacy and
Pharmaceutical Sciences, 4-7 September 1994,
Istanbul,Turkey.
(Lecture)
15. M.Ulgen, F.Yilmaz, S.Unsalan, J.W.Gorrod.
"Chemical and metabolic studies on
N-benzyl-tert-butylamine and its potential
metabolites"
First International Meeting on Pharmacy and
Pharmaceutical Sciences, 4-7 September 1994,
Istanbul.
16. I.Kucukguzel, M.Ulgen, J.W.Gorrod.
"In vitro microsomal metabolism of N-benzylic
tertiary amines"
First International Meeting on Pharmacy and
Pharmaceutical Sciences, 4-7 September 1994,
Istanbul.
17. N.Gulerman, S.Rollas, M.Ulgen, J.W.Gorrod.
"Synthesis and evaluation of some substituted
1,3,4-thiadiazole derivatives as
antimicrobial agents"
First International Meeting on Pharmacy and
Pharmaceutical Sciences, 4-7 September 1994,
Istanbul.
18. S.Unsalan, F.Yilmaz, I.Kuçukguzel, M.Ulgen,
J.W.Gorrod.
"Synthesis,characterisation and chromatographic
studies
on benzylic tertiary amines and their potential
metabolites"
4th International Symposium of Pharmaceutical
Sciences.Ankara University, Faculty of Pharmacy,
June 27-30 1995, Ankara.
19. M.Ulgen, K.Erçak, I.Kuçukguzel, J.W.Gorrod.
"In vitro microsomal metabolic studies on
secondary
aromatic amides"
2nd Xenobiotic Metabolism and Toxicity Workshop
of
Balkan Countries, 22-25 October 1995, Ioannina,
Greece.
20. P. Jacob III, M. Ulgen and J.W. Gorrod.
"The metabolism of (S)-(-)-Nicotine by Guinea
Pig and Rat
Brain: Identification of Cotinine"
The Society for Research on Nicotine and Tobacco
3rd Annual Scientific Conference
June 13-14, 1997 , Nashville, TN, USA.
21. I. Kucukguzel and M. Ulgen
In vitro metabolic fate of N-substituted
dibenzylamines: Investigation of
biological oxidation site on nitrogen compounds
with different pKa
5th International Symposium on Pharmaceutical
Sciences
June 24-27,1997, Ankara University, Faculty of
Pharmacy, Ankara.
22. N.Tunç, F. Yılmaz, M.Ulgen and J.W.Gorrod
In vitro rat hepatic microsomal metabolism of
phenanthridine
5th International Symposium on Pharmaceutical
Sciences
June 24-27, 1997, Ankara University, Faculty of
Pharmacy, Ankara.
23. N. Eldirdiri, M. Ulgen, P. Jacob and J. W.
Gorrod,
"The in vitro metabolism of norcotinine and
related
biotransformation products by microsomal
preparations"
Symposium on Drug Metabolism : "Towards to the
next millenum"
King's College, Chelsea Department of Pharmacy,
August 25-27, 1997, London, UK.
24. I. Kuçukguzel, M. Ulgen and J. W. Gorrod
"In vitro microsomal metabolism of chlorine
substituted secondary amines and imines"
Symposium on Drug Metabolism : "Towards to the
next millenum"
King's College, Chelsea Department of Pharmacy,
August 25-27, 1997, London, UK.
25. N. Gülerman, S. Rollas and M. Ulgen.
"Synthesis and in vitro microsomal metabolism of
4-ethyl-5-(4-fluorophenyl)-
2,4-dihydro-3H-1,2,4-triazole-3-thione and its
potential metabolites"
First International Symposium on Pharnaceutical
Chemistry
Hacettepe University, Faculty of Pharmacy,
Ankara Turkey
September 24-26, 1997 Ankara.
26. I.Kuçukguzel, M.Ulgen and J.W.Gorrod.
Effect of nitrogen pKa on the microsomal
oxidation of N-benzylic eterocycles
First International Symposium on Pharnaceutical
Chemistry
Hacettepe University, Faculty of Pharmacy,
Ankara Turkey
September 24-26, 1997 Ankara.
27. F. Yılmaz, M. Ulgen, D.S. Doğruer, B. Çakır
and M.F. Şahin
The in vitro hepatic metabolism of
1-phenyl-2-(2-benzothiazolinone-
3-yl)ethanone and
(+)-1-phenyl-2-(2-benzothiazolinone-3-yl)ethanol,
Microsomes and Drug Oxidations, 1998 Upsala,
Sweeden.
28. F. Yılmaz, M. Ulgen and J.W. Gorrod
The in vitro hepatic microsomal metabolism of
N-benzyladamantanamine in rats
Second International Meeting on Pharmacy and
Pharmaceutical Sciences,
6-9 September 1998, Istanbul.
29. B. Kaymakçıoğlu, E. Oruç, S. Rollas and M.
Ulgen
The in vitro hepatic microsomal metabolism of
3,5-dimethyl-4-phenylazo
(1H) pyrazole in rats
Second International Meeting on Pharmacy and
Pharmaceutical Sciences,
6-9 September 1998, Istanbul.
30. M. Ulgen, F. Yılmaz, D. S. Doğruer and M. F.
Şahin
The in vitro hepatic microsomal metabolism of
methyl 2-(2(3H)-
benzoxazolone-3-yl)acetate in rats
Second International Meeting on Pharmacy and
Pharmaceutical Sciences,
6-9 September 1998, Istanbul.
31. G. Küçükgüzel, İ. Küçükgüzel and M. Ülgen
In vitro microsomal metabolism of
N-(4-chlorobenzyl)-N'-benzoylhydrazine
Second International Meeting on Pharmacy and
Pharmaceutical Sciences,
6-9 September 1998, Istanbul.
32. M. Ulgen and J.W. Gorrod
Studies on the in vitro hepatic microsomal
formation of amides during the
metabolism of certain secondary and tertiary
benzylic amines
9th North American ISSX Meeting
Nashville, Tennessee, 1999
33. Ş.G.Küçükgüzel, İ. Küçükgüzel and M. Ulgen
Metabolic and chemical studies on
N-(4-chlorobenzyl)-N’-benzoylhydrazine
9th North American ISSX Meeting, Nashville,
Tennessee, 1999
34. B. Çakır , D.S. Doğruer , M.F. Şahin , F.
Yılmaz and M. Ulgen
The in vitro hepatic microsomal metabolism of
3-(3-morpholinylpropyl)—2-
benzothiazolinone in rats
9th North American ISSX Meeting
Nashville, Tennessee, 1999
35.Yılmaz,F. And Ulgen, M.
“In vitro metabolism of N-benzoylnornicotine and
N-(p-chlorobenzyl)nornicotine
4th Xenobiotic Metabolism and Toxicity Workshop
of Balkan Countries”
12-16 April, 2000, Antalya, Türkiye.
36.Oktav,M., Sözen,M., Zelzele,Ö., Özakun, C.
And Ulgen, M.
“Xenobiotics in Printing Industry”
4th Xenobiotic Metabolism and Toxicity Workshop
of Balkan Countries”
12-16 April, 2000, Antalya, Türkiye.
37.Önkol, T., Şahin, M.F., Kartal, F., and
Ulgen, M.
“The in vitro hepatic microsomal metabolism of
1-[2-[2(3H)-benzothiazolone-3-yl]acetyl]piperidine
in rats”
DMW/ISSX 2000 Meeting, June 11-16,2000,
St.Andrews, Scotland.
38. Şimşek,R., Şafak,C., Oral,B., Bulut,G.,
Ulgen,M.
“The in vitro hepatic microsomal metabolism of
2,6,6-trimethyl-3-carbmethoxy-4-(2-bromophenyl)-5-oxo-1,4,5,6,7,8-hexahydroquinoline
in rats”
10th North American ISSX Meeting,
Indianpolis,Indiana,2000.
39.Şekercioğlu,Y., Oktav,M., Dölen,E.,
Rollas,S., Ulgen, M.
“In vitro rat microsomal metabolism of aromatic
azo dyes used in the printing inks”
10th North American ISSX Meeting,
Indianpolis,Indiana,2000.
40.Yurtsever,E., Şener,A., Göker,B., Ulgen,M. ,
Yardımcı,T.
“Effect of tenoxicam on plasma and liver lipid
peroxidation and glutathione
levels in wistar albino rats”
10th North American ISSX Meeting,
Indianpolis,Indiana,2000.
41.Ulgen,M., Gorrod,J.W.
“The source of amides observed during the
microsomal metabolism of N-benzylamines”
10th North American ISSX Meeting,
Indianpolis,Indiana,2000.
42. Oktav, M., Sözen, M., Zelzele, Ö., Özakun,
C., Ülgen, M.
“A toxicity evaluation of printing chemicals
used in the packaging of pharmaceutical
formulations”
1st International Pharmaceutical Congress, April
28-29,2001, Athens
43. Kaymaz, S., Bulut, G., Ülgen, M.
“In vitro microsomal metabolic studies on
secondary aromatic hydroxamic acids and their
corresponding amides”
1st International Pharmaceutical Congress, April
28-29,2001, Athens
44. Ulgen, M.
“The sources of chemical artifacts in the in
vitro metabolism of xenobiotics”
3rd International Symposium on Pharnaceutical
Chemistry
Hacettepe University, Faculty of Pharmacy,
Ankara Turkey
September 17-19, 2001, İstanbul (oral
presentation)
45. Yılmaz,F., Ulgen, M., Gorrod, J.W.
“The In Vitro Hepatic Microsomal Metabolism Of
Some Alkylated
And Acylated Nornicotine Derivatives”
14th International Symposium on Microsomes and
Drug Oxidations
Sapporo, Japan, July 22-26, 2002.
46. Duran, A., Bekçe, B., Doğan,N. And Ulgen, M.
"Simultaneous determination of salmeterol and
fluticasone propionate
by high performance liquid chromatography“
Fourth International Symposium on Pharnaceutical
Chemistry
Hacettepe University, Faculty of Pharmacy,
Ankara Turkey
September 17-19, 2003 İstanbul.
47. Banu Bekçe , Göksel Şener, Mehmet Oktav,
Mert Ulgen and Sevim Rollas
“In vitro and in vivo metabolism of ethyl
4-[(2-hydroxy-1-naphthyl)azo]
benzoate”
19th European Workshop on Drug Metabolism
October 03-08, 2004. Antalya-Turkey.
48. Gülen Bulut, Mehmet Oktav and Mert Ulgen
“The stabılıty studies and in vıtro hepatic
microsomal metabolism of
some a-phenyl-N-substituted nitrones in rats”
19th European Workshop on Drug Metabolism
October 03-08, 2004. Antalya-Turkey.
49. Demircan, F.Y., Ulgen, M.
“High pressure liquid chromatographic method for
the determination of nicotine metabolites and
their
in vitro metabolism by rat brain”
MCRD 2005 International Symposium on Medicinal
Chemistry Research and Development 2005
Kuşadası Turkey p-38.
50. Koçyiğit-Kaymakçıoğlu, B., Oruç, E.E.,
Yılmaz-Demircan, F., Gürbüz, Y., Kalaça, S.,
Küçükgüzel,
Ş.G., Ülgen, M., Rollas, S.
“An high performance liquid chromatographic
method for the quantification of cotinine in the
urine of preschool children” MCRD 2005
International Symposium on Medicinal Chemistry
Research and Development 2005
Kuşadası Turkey p-47.
51. Ö. Algül, M. Ülgen,
"The In Vitro Hepatic Microsomal Metabolism of
2-Substitutedbenzimidazoles in Rats"
8th. International Symposium of Pharmaceutical
Sciences. P-215, 13-16 Haziran 2006, Ankara,
Turkey
6. Ulusal bildiriler :
1. M. Ulgen
"İlaç metabolizmasının ve bu konuda yapılacak
çalışmaların Eczacılık mesleği açısından önemi"
V. Türkiye Eczacılık Kongresi, 21-23 Mayıs 1993,
Sherton Oteli, İstanbul. (Sözlü Bildiri)
2. I.Kuçukguzel, M.Ulgen and J.W.Gorrod
"In vitro hepatıc microsomal metabolism of
N-benzyl-N-methylaniline by rat :
The detection of p-hydroxylated metabolites by
HPLC"
2nd National Congress of Toxicology with
International
Participation April 3-6, 1997 İberotel-Berpark,
Antalya, Turkey
3. M. Ülgen
"Organik Bileşiklerin Metabolizması"
XIII. Kimya 99 Ulusal Kimya Kongresi
31 Agustos-4 Eylül 1999
Ondokuz Mayıs Üniversitesi Fen - Edebiyat
Fakültesi
Kimya Bölümü, Samsun
(Sözlü Bildiri)
4. Oktav, M., Özhakun, C., Ülgen,M.
"Matbaacılıkta Sağlık ve Üretimi Etkileyen
Kimyasal Faktörler"
XIII. Kimya 99 Ulusal Kimya Kongresi
31 Agustos-4 Eylül 1999
Ondokuz Mayıs Üniversitesi Fen - Edebiyat
Fakültesi Kimya Bölümü, Samsun
5. Oktav, M., Şekercioğlu, Y., Zelzele, Ö.,
Ülgen, M.
“Karton ambalaj sektöründe sağlığı ve
işgüvenliğini olumsuz etkileyen faktörlerin
önlenmesine yönelik
inceleme”
II. Uluslararası ambalaj kongresi ve sergisi
30 Mayıs- 1 Haziran, 2001 Dokuzeylül
Üniversitesi Sempozyum Salonları Desem İzmir
6. Ülgen, M., Özcan, A., Yaman, Ö., Karatepe,
A.K.
“Basım İşletmelerinde Gürültünün İşgörenin
Performansı Üzerine Olumsuz Etkisinin
İncelenmesi”
1. Uluslar arası katılımlı Kağıt-Karton,
Mürekkep, Matbaa Sempozyumu Sergisi
26-28 Eylül 2002, Narlıdere İzmir |
|
|
|
|
